Compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 ± 0.008 μM, and exhibited the strongest inhibitory activities against A549, MCF-7 and MKN-45 cancer cell lines with IC50 values of 7.3 ± 1.0 μM, 6.1 ± 0.6 μM, and 13.4 ± 0.5 μM, respectively. This evidence concerns the gene MET and cancer.