ApoE is present in almost all serum lipoproteins and acts as aprotective factor in atherosclerosis due its interaction with receptor-mediatedlipoprotein clearance and cholesterol receptor.1,3,4,7,8,17 ApoE gene islocated on chromosome 19q13.2, and has three common alleles: e2, e3, and e4. The gene discussed is APOE; the disease is atherosclerosis.