Apolipoprotein (ApoE) is acomponent of human lipoproteins, with a molecular weight around 39kD, which servesas a ligand for cellular uptake of triglyceride-rich lipoproteins through specificreceptors of the LDL receptor.7,8,9,10 Identification of ApoE isoforms E2/3, E2/4, E3/3, and E4/4 canestablish the diagnosis of LPG. This evidence concerns the gene APOE and lipoprotein glomerulopathy.