APOE and nephrotic syndrome: The mutations of ApoE more frequently implicated with LPG areApoE Sendai (Arg145Pro), ApoE Kyoto (Arg25Cys), ApoE Tokyo, ApoE1, ApoEGuangzhou (Arg150Pro), ApoE Maebashi, ApoE Tsukuba, ApoE Chicago, and ApoEOkayama.4,6,15,23,26,30,34 AbnormalapoE proteins determine mesangial and basement membrane alterations, which areassociated to increased glomerular permeability and nephrotic syndrome withhigher levels of LDL, VLDL, and apolipoproteins B, C-II, and C-III.