ApoE Sendai can break theα-helical structure of ApoE in the low-density lipoproteinreceptor-binding domain and modify the ApoE protein that are deposited inglomeruli thrombi and mesangium.2,7,8,19,21,39,40 In ApoEKyoto, a substitution of cysteine for arginine-25 can be found.19,21,34,41,42 The isoformsE2 and E4 can also be implicated with atherosclerosis. Here, APOE is linked to atherosclerosis.