APOE and lipoprotein glomerulopathy: Arg25Cys is a common mutation of ApoE gene and is known as ApoE Kyoto.12,19,21 Huet al. presented 35 LPG patients carrying the ApoE Kyoto allele in southwestChina, making it a frequent mutation related to LPG.21 Hu performed a family study and found that the patient'smother was a heterozygous carrier of apoE Kyoto and his father was a carrier ofCys112Arg.