EP300 and pulmonary arterial hypertension: For example, EP300 functions as histone acetyltransferase to regulate transcription of genes via chromatin remodelling, overexpression of which could alter the expression levels of ECM proteins and VEGF in endothelial cells.31 In a word, both the common miRNAs and ceRNAs of the key ceRNA‐mediated subpathways have been suggested to be closely associated with PAH.