Specifically, all the nonredundant ceRNAs associated with PTEN were collected from the corresponding ceRNA interactions as a gene set S. Based on one PTEN gene knockdown profile of breast cancer cell line (GSE7562), lists of genes ranked according to their values of fold change, from the most up‐regulated (at the top of the list) to the most down‐regulated (at the bottom of the list), which was as a background gene list L. Actually, when PTEN was knockdown, PTEN‐related ceRNAs should be expression down‐regulated because ceRNA interaction pairs were positively correlated. The gene discussed is PTEN; the disease is breast cancer.