CD147, a transmembrane glycoprotein, belongs to the immunoglobulin superfamily and is widely expressed on the surface of cancer cells.6 Reports showed that CD147 was over‐expressed in many types of cancer, such as human malignant melanoma, hepatocellular carcinoma, lung cancer, gastric cancer, breast cancer and so on.7, 8, 9, 10, 11, 12 CD147 is also reported to involve in tumor progression, angiogenic function and immune response.13, 14. This evidence concerns the gene BSG and hepatocellular carcinoma.