BSG and neoplasm: As studies have shown, CD147 enhanced tumor growth through NF‐kappa B signalling.21, 22 To observe the time‐dependent activation of NF‐kappa B signaling, negative control cells and shCD147 cells were treated with serum‐free DMEM overnight, subsequently stimulated with TNFα and cells were harvested at 0, 5, 15, 30, 60 and 120 min.