As our previous study shown, CD147 is considered to be a HNSCC cell surface marker that could enhance the tumor initiation and progression.5 Studies also demonstrated that CD147 had negative role in regulating in T cell‐mediated immune responses and drugs targeting CD147 had anti‐angiogenesis and anti‐invasion activity.25, 26, 27, 28 Our data determined that CD147 exerted positive effect on tumorigenicity and cancer progression of HNSCC both in vitro and in vivo. This evidence concerns the gene BSG and cancer.