As studies have shown, CD147 enhanced tumor growth through NF‐kappa B signalling.21, 22 To observe the time‐dependent activation of NF‐kappa B signaling, negative control cells and shCD147 cells were treated with serum‐free DMEM overnight, subsequently stimulated with TNFα and cells were harvested at 0, 5, 15, 30, 60 and 120 min. Here, TNF is linked to neoplasm.