Using Trem2−/− 5xFAD transgenic mice, mutations in triggering receptor expressed on myeloid cells 2 (TREM2) can lead to energy dysfunctions in the immune cell microglia and thereby cause impaired clearance of amyloid plaques; energy supplementation with cyclocreatine to immune cells reduces the plaque load to protect the neurons [58]. Here, TREM2 is linked to amyloidosis.