An inability of the tissues to regulate calcium levels has been associated with the development of type 2 diabetes mellitus (T2DM) due to defects in both insulin secretion and action, thus leading to Ca2+ dyshomeostasis [6] and oxidative stress (OS) in the tissues [3, 7–9]; however, little is known about the mechanism of action of several ethnomedical plants used in the management of T2DM in several developing countries. Here, INS is linked to type 2 diabetes mellitus.