To investigate whether Flt3-ITD inhibition exerts antileukemic activity via modulation of the Myc network, we treated the human Flt3-ITD mutated leukemia cell line, MV4-11, with PKC412 at two different concentrations (0.1 mM and 1 mM) and analyzed the expression of Myc network genes. The gene discussed is FLT3; the disease is leukemia.