Furthermore, inhibition of CXCL12 with the L-RNA-aptamer NOX-A12, which impedes CXCL12 interaction with CXCR4 and CXCR7, led to greater tumor infiltration by T and natural killer (NK) cells with an improved anti-PD1 therapy in a mouse model of colorectal cancer (77). This evidence concerns the gene CXCR4 and neoplasm.