Interestingly, therapy such as peptide vaccination in Montanide Adjuvant led to the upregulation of CXCR3 expression on circulating tumor antigen-specific T cells (121) but Hailemichael et al. have shown that most of these CXCR3+ T cells induced by the vaccination are retained to the site of vaccine administration (122). The gene discussed is CXCR3; the disease is neoplasm.