On the other hand, they are involved in tumor escape and metastases formation by (i) selectively guiding tumor cells toward specific organs, which subsequently form secondary lesions (e.g., CCR7 or CXCR4), (ii) favoring the recruitment of immunosuppressive cells (e.g., CCR5) and, (iii) influencing tumor vasculature associated with tumor dissemination (e.g., CXCL10 and CXCR3) (140, 141). The gene discussed is CXCR3; the disease is neoplasm.