CXCR1/2 is expressed on melanoma cells, MDSC and neutrophils and sustains tumor immunosuppression, tumor growth, angiogenesis and tumor dissemination in response to CXCL1, CXCL2 or CXCL8 (107, 108, 159–164) (Tables 1, 2). Here, CXCL2 is linked to neoplasm.