Transcriptomic analyses of 569 cutaneous samples and 120 melanoma metastases have demonstrated the positive association of 12 chemokines (CCL2, CCL3, CCL4, CCL5, CCL8, CCL18, CCL19, CCL21, CXCL9, CXCL10, CXCL11, and CXCL13) with the presence of tertiary lymphoid structures, ectopic lymph node-like structures containing antigen presenting cells, B cells and T cells (85). This evidence concerns the gene CCL21 and melanoma.