Transcription factors NFAT (52), GATA4, and MEF2C (53) induce a cardiac hypertrophy gene expression program, e.g., inducing atrial (ANP) and B-type (BNP) natriuretic peptide mRNA expression, following their activation by O-GlcNAcylation. The gene discussed is NPPA; the disease is cardiac hypertrophy.