INS and diabetes mellitus: This large-scale survey demonstrated that T2DM outpatients treated with premixed insulin monotherapy had a better glycemic control reaching normal HbA1c of <7% than those outpatients on basal insulin monotherapy, and this result was further confirmed by the better efficacy of premixed insulin over basal insulin treatment stratified by the different subgroups of gender, BMI, duration of diabetes, presence of complications, and comorbidities.