CYBB and acute respiratory distress syndrome: Five days after ARDS induction, levels of NADPH oxidase- (NOX-) 1, NOX-2, and oxidized protein, three indicators of oxidative stress, were the highest in untreated ARDS rats, were significantly and progressively reduced across the ARDS + SW, ARDS + Mito, and ARDS + SW + Mito groups, and the lowest in the SC group (Figure 9).