ESR1 and breast cancer: In our study, 19,989 genes were analyzed and after prioritization analysis we obtained a top ranking of 1842 genes where the top 10 genes with highest ranking were TP53, ESR1, BRCA2, BRCA1, ERBB2, CHECK2, CCND1, AR, RAD51 and ATM; and where 137 of 145 (94.5%) predefined pathogenic genes associated with BC were identified.