Consistent with the link between MYC/MYCN and catastrophic events that we identified in the murine XRCC4/p53 MBs, gains or focal amplifications of the MYC or MYCN loci were detected at higher frequencies in human tumors with complex genome rearrangements as compared to cases without complex genome rearrangements, both in glioblastomas and in SHH MBs (Supplementary Data 2). This evidence concerns the gene MYCN and glioblastoma.