Whole-genome sequencing of the tumors developing in BRCA2/p53, XRCC4/p53, or Lig4/p53-deficient animals showed frequent complex genomic rearrangements (Fig. 1a–c, Supplementary Figure 1), with a prevalence of 64% in the XRCC4/p53-deficient mice (n = 11 MBs), 60% in the Lig4/p53-deficient mice (n = 5 HGGs), 71% in the BRCA2/p53-deficient HGGs (n = 7), and 33% in the BRCA2/p53-deficient MBs (n = 3) (Fig. 1c, Supplementary Data 1). Here, TP53 is linked to Mobius syndrome.