A significant ARID5B low expression was observed in B-ALL patients that were IK6 + (0.3153 ± 0.0938 vs. 1.2052 ± 0.58441, P = 0.02439) (Fig. 3d), which is consistent with our finding that the ARID5Blow cohort has a significantly higher percentage of IK6 + cases in B-ALL (Table S1). The gene discussed is ARID5B; the disease is acute lymphoblastic leukemia.