Stengel et al. investigated targeted RNA sequencing by NGS for the detection of reciprocal rearrangements in 58 AML cases with suspected novel fusions based on the detection of only one partner gene (RUNX1, ETV6, PDGFRB, KMT2A, RARA, NPM1, MECOM, PDGFRA, BCOR, TET2, NUP98) by chromosome banding analysis and FISH. This evidence concerns the gene NPM1 and acute myeloid leukemia.