Besides the three classical mutations in JAK2, CALR, and MPL that are commonly referred to as MPN driver mutations, non-driver mutations in the genes known from MDS and AML are also detected in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF)15,17,18. The gene discussed is CALR; the disease is myeloproliferative disorder.