In the human LRRK2 promoter, seven putative HRE sites were identified (Supplementary Fig. 10A), and we confirmed that pcDNA3-HA-HIF-1α-WT markedly increased the luciferase activity of the human LRRK2 reporter plasmid, pGL3-hLRRK2-Luc in human neuroblastoma SH-SY5Y cells (Supplementary Fig. 10B), suggesting that transactivation of LRRK2 by HIF-1α may be a conserved mechanism. This evidence concerns the gene LRRK2 and neuroblastoma.