Additionally, the expression of endothelial nitric oxide synthase (eNOS) was upregulated in sVEGFR3 mice 8 days after MI compared to controls (p = 0.07) indicating that the expression of sVEGFR3 may induce changes in the heart vasculature during MI by modulating VEGFR2-mediated vascular permeability. Here, NOS3 is linked to myocardial infarction.