We compared the diagnostic values of miR-33a-5p, miR-128-3p and their combination with three commonly used tumor markers (cytokeratin-19-fragment (CYFR21-1), neuron-specific enolase (NSE) and cancer antigen 72-4 (CA72-4)), and obtained the following AUC values: CYFR21-1, 0.5856 (95% CI = 0.4387 to 0.7324, sensitivity = 63.33% and specificity = 63.33%, Fig. 5A,D), NSE, 0.6189 (95% CI = 0.4748 to 0.763, sensitivity = 73.33% and specificity = 56.67%, Fig. 5B,D), CA72-4, 0.5206 (95% CI = 0.3684 to 0.6727, sensitivity = 86.67% and specificity = 36.67%, Fig. 5C,D). The gene discussed is KRT19; the disease is neoplasm.