IFNL1 and infection: In order to shed light on the mechanisms that underlie the discrepancies between HEV-1 and HEV-3 replication at the maternal-fetal interface, we assessed the secretion profiles of type I (IFN-α2 and -β), type II (IFN-γ) and type III (IFN-λ1, -λ2/3) IFNs in tissue culture supernatants 2 days post infection (Fig. 5).