EIF2AK2 and leukemia: Fas signalling has been shown to be activated by NF-κB at the transcriptional level22,23 and PKR-induced apoptosis depends on the activation of Fas by NF-κB.21,24 Noteworthy, plitidepsin has been shown to induce the extrinsic apoptotic pathway in Jurkat leukaemia cells.25,26 Thus, we analysed whether plitidepsin was activating the extrinsic apoptotic pathway also in HeLa cells.