EEF1A2 and neoplasm: Moreover, eEF1A2 has been demonstrated to confer neoplastic characteristics to preneoplastic, nontumourigenic human ovarian precursor cells4 and to NIH-3T3 mouse fibroblasts.2 Although the canonical function of eEF1A2 is delivering aminoacyl-transfer RNAs to the ribosome during translation, other “moonlighting” functions have been described for the protein.5 For example, sphingosine kinase 1 (SPHK1) activity is enhanced by direct interaction with the guanosine diphosphate (GDP)-bound form of eEF1A26,7 favouring tumour cell growth.