HIF1A and cancer: However, cytotoxic chemotherapy using 5-fluorouracil (5-FU), oxaliplatin, and irinotecan is used frequently to slow down the growth of incurable metastatic colorectal cancers.15,16 Recently, we reported that IDF-11774, a novel clinical candidate, stimulates hypoxia-inducible factor alpha (HIF-1α) degradation, presumably by inhibiting HSP70 chaperone activity.17,18 IDF-11774 regulates cancer metabolism by activating AMP-activated protein kinase (AMPK).17