Curcumae Longae Rhizoma can reduce the kidney hypertrophy index of DN induced by streptozocin(STZ) and reduce the level of urinary albumin excretion rate (UAER), its protective effect on DN mainly by reduced the overexpression of TGF-β1 and prevented renal fibrosis in DN22,23. The gene discussed is TGFB1; the disease is renal fibrosis.