For instance, PARP3 is involved in the DDR and mitotic spindle assembly [50]; PARP4 (vPARP or ARTD4) has an unclear function at the mammalian vaults (ribonucleoprotein complexes) and it is possibly involved in antiviral response [51,52]; PARP6 has been proposed to have a role in cell cycle progression and has been associated with the development of colorectal cancer [53]. The gene discussed is PARP4; the disease is colorectal cancer.