Paralog-conserved analysis did not reveal association with schizophrenia for individual voltage-gated sodium channel genes at the level required to demonstrate association (i.e., exome-wide significance) (Table S6 in Supplement 2) or even after adjusting for the experiment-wide context of 187 genes, although SCN7A showed a nominal signal (puncorrected = .001). The gene discussed is SCN7A; the disease is schizophrenia.