Among these targeted genes, we had complete membership of four gene sets: ARC and NMDAR postsynaptic protein complexes, which have been strongly implicated in multiple previous studies 9, 10, and voltage-gated sodium (17) and calcium (8) channels, which have inconclusive evidence for association with schizophrenia in previous rare variant studies 7, 17. This evidence concerns the gene ARC and schizophrenia.