SETD2 and central nervous system neoplasm: Here we describe 19 cases of CNS tumors with mutations in SETD2. SETD2 mutation allele frequency and co-occurring mutations in other genes are investigated, and results are correlated with the effects of SETD2 mutations on epigenetic change, specifically histone methylation and acetylation as shown by immunohistochemistry for H3K36me3, H3K36ac and H3K27me3.