The remaining missense mutations found in SETD2 may represent changes found with the increased mutational load seen with tumor recurrence in this cohort (4.57 ± 3.40 mutations in recurrent tumors vs. 1.41 ± 1.24 mutations in primary tumors, p < 0.01), and known in the literature, particularly after treatment with temozolomide [3, 9]. The gene discussed is SETD2; the disease is neoplasm.