As presented in Table 2, univariate Cox regression analysis indicated that GAP43 and PMP2 were risk genes for NSCLC brain metastasis (crude HR: 2.12; 95% CI 1.09–4.13; P = 0.027 for GAP43; crude HR: 2.12; 95% CI 1.05–4.30; P = 0.036 for PMP2). The gene discussed is GAP43; the disease is non-small cell lung carcinoma.