As reported, tumor cells arrested at the brain vascular branch can adhere to the endothelium and secrete certain cytokines, such as matrix metalloproteinases (MMPs), placental growth factor (PLGF) and vascular endothelial growth factor (VEGF), to break the tight junction and promote retraction of the endothelial monolayer [10–12]. Here, VEGFA is linked to neoplasm.