We conducted subgroup analyses by ethnicity using Asian studies, but we did not find any significant associations of the ICAM-1 rs5498 polymorphism with retinopathy in Asians (dominant model: OR = 0.96, 95% CI: 0.61–1.50, P = 0.843; recessive model: OR = 1.15, 95% CI: 0.79–1.68, P = 0.469; GG versus AA contrast: OR = 1.04, 95% CI: 0.60–1.81, P = 0.887; G allele versus A allele: OR = 1.05, 95% CI: 0.76–1.44, P = 0.790) (Table 2 and Figs. 2 and 3). Here, ICAM1 is linked to retinal disorder.