BAX and melanoma: Some studies suggested RBM3 to induce cell proliferation and inhibit the DNA damage response machinery and cell death [6, 22, 23], while others suggested RBM3 to be positive associated with the pro-apoptotic BAX gene [10], to be downregulated in an in vitro model of melanoma progression [24], and to enhance platinum-sensitivity in vitro in ovarian cancer [18].