At the molecular level, using Western blotting, we found that both c-Met/β-cateninS45Y and c-Met/∆N90-β-catenin HCC lesions showed expression of ectopically injected human c-Met (Fig. 4), and c-Met was activated as demonstrated by the high phosphorylated(p)-Met levels. This evidence concerns the gene MET and hepatocellular carcinoma.