CASP3 and neoplasm: At the end of the experiments, there was an increased Caspase-3 (active) and decreased CD31 expression found in the tumour xenografts of PC-3-EpCAM-KD CaP cells compared to PC-3-EpCAM-scr group (Additional file 3: Table S3), suggesting that increased apoptosis (active Caspase-3) and reduced angiogenic activity (CD31) were found in response to DTX treatment after KD of EpCAM.