Additionally, KD of EpCAM was found to sensitise the tumour to chemo−/radiotherapy and improved MS of tumour-bearing mice which received DTX (50 mg/kg, single dose, i.p.)by 11 days (HR = 20.95, CI95% 3.599–121.9, P = 0.0007) (Fig. 5b), and RT (2Gy/day for 4 days) by 12 days (HR = 11.00, CI95% 2.11–57.36, P = 0.0044) (Fig. 5c) when compared with the control group mice (PC-3-EpCAM-scr s.c. xenografts), respectively (Additional file 2: Table S2). Here, EPCAM is linked to neoplasm.