This epigenetic regulation was variable depending on the AML cell line: in NPM1- and DNMT3A-wild type U937 cells, treatment by 1 mM VPA alone did not induce any modification in HOXB4 or miR-10a levels whereas 2 μM DEOX alone did induce overexpression of both transcripts. This evidence concerns the gene DNMT3A and acute myeloid leukemia.