Interestingly, in contrast to previous reports, treatment with SAHA or 5-aza-dC did not significantly alter PKD1 expression at both mRNA and protein levels in four out of five HNSCC cell lines examined with the exception of UMSCC-1 (Fig. 3 and Additional file 1: Figure S2). The gene discussed is PKD1; the disease is head and neck squamous cell carcinoma.