Interestingly, in a small cohort of metastases (15 lymph node metastases and one liver metastasis), a significant reduction of PKD1 expression was observed in distal metastases as compared to the localized primary tumors (p = 0.002), suggesting a reverse correlation with tumor metastasis (Fig. 1d). The gene discussed is PKD1; the disease is metastatic malignant neoplasm in the lymph nodes.