Consistently, in a murine model of acute viral hepatitis caused by LCMV-WE, maturation of dendritic cells (DCs) and increased CD8+ and CD4+ T cells producing IFN-γ have been observed in FGL2 knock-out mice infected with LCMV-WE, demonstrating a crucial role of FGL2 in the immune response against hepatitis viruses [18]. Here, CD4 is linked to viral hepatitis.