Thirteen of these pathways (Integrin, Clathrin-mediated Endocytosis, Antigen Presentation, Rho Family GTPases, RhoA, RhoGDI, CD28 in T Helper Cells, Actin Cytoskeleton, mTOR, Rac, Remodeling of Epithelial Adherens Junctions, Tight Junction, and Role of NFAT) were enriched in the ICM-specific Analysis 2 in the same z-score directions, suggesting their significance in this comparison is due to upregulated genes in ICM rather than downregulated genes in DCM. The gene discussed is CD28; the disease is familial dilated cardiomyopathy.