Thirteen of these pathways (Integrin, Clathrin-mediated Endocytosis, Antigen Presentation, Rho Family GTPases, RhoA, RhoGDI, CD28 in T Helper Cells, Actin Cytoskeleton, mTOR, Rac, Remodeling of Epithelial Adherens Junctions, Tight Junction, and Role of NFAT) were enriched in the ICM-specific Analysis 2 in the same z-score directions, suggesting their significance in this comparison is due to upregulated genes in ICM rather than downregulated genes in DCM. This evidence concerns the gene RHOA and familial dilated cardiomyopathy.