In a similar approach to mine pathway entries in the KEGG database, the common denominator was found as hypertrophic cardiomyopathy (HCM, KEGG entry hsa05410) containing the cluster IL6, ITGB3 and ACTG1 (Table 3), linking it to the ECM-receptor interaction, renin-angiotensin system JASK-STAT signalling pathway and TGFbeta-signalling pathway. Here, REN is linked to hypertrophic cardiomyopathy.