CNR2 and colitis: DNBS colitis is worsened by prophylactic administration of the CB1 antagonist SR141716A,67 with DSS and oil-of-mustard colitis improved by prophylactic ACEA, a CB1 agonist.70 Similarly, the CB2 agonists JWH133,70 HU308,69 or ALICB45971 are beneficial in ameliorating chemical colitis models when administered prophylactically.