Although most studies have used chemical colitis models, JWH133 ameliorates colitis in the IL10-/- model where mice develop spontaneous colitis by 12 weeks of age.73 GP-1a, purported to be a CB2 agonist, improves ileitis when administered retro-orbitally in the TNFΔARE model of Crohn’s-like ileitis. This evidence concerns the gene CNR2 and colitis.