CNR1 and Alzheimer disease: Since endocannabinoids such as anandamide have been reported to have preventive properties against Aβ-induced impairments in WT and AD animal models in vitro and in vivo (Aso and Ferrer, 2014), we first investigated whether cannabinoid receptor (CB1 and CB2) activation could prevent the Aβ-induced reduction of gamma oscillations.