Wnt signalling plays important roles during the development and progression of cancer, including NSCLC.1, 2, 3, 4, 5, 6 We previously observed that Zbed3 is overexpressed in NSCLC tissues compared to normal lung tissues and is associated with cancer development.7 Down‐regulation of Zbed3 in lung cancer cells significantly reduced expression of β‐catenin and p120‐catenin 1, both of which are degraded through similar pathways, but the mechanism involved is not completely clear. This evidence concerns the gene ZBED3 and non-small cell lung carcinoma.