Moreover, the published evidence has demonstrated that the MMPs such as MMP‐2 and MMP‐9 play an important role on metastasis of malignant tumours for degrading the basement membrane and promoting invasion.29 Therefore, we investigated the expression of MMP‐2 and MMP‐9, and TIMP2 in HepG2 cell, which is involved in BA‐mediated migration and invasion. Here, TIMP2 is linked to cancer.