PLAU and ischemic stroke: Additionally, the use of PlauGFDhu/GFDhu mice in which a 4 aa substitution into the growth factor domain of uPA precludes its binding to uPAR while preserving other functions of the protease and its receptor [36] indicated that binding of endogenous uPA to uPAR in the perinecrotic area promotes the recovery of dendritic spines following an ischemic stroke.