Among these factors, we focused on the Notch pathway since NOTCH1 mutations are relatively specific to oligodendroglioma among diffuse gliomas; occur in a substantial subset (18–31%) compared to BCOR and ZBTB20; and represent one component of the Notch signaling network that could be more generally relevant to disease progression. The gene discussed is ZBTB20; the disease is oligodendroglioma.