A comparison of the PBMC response to extracts of spore-forming bacteria from controls or from MS patients identified lower conversion into CD4+ FoxP3+ Tregs (Fig. 2A and C), including the IL-10-expressing Treg population (Fig. 2B and D) in the PBMCs exposed to the MS-derived spore-forming bacteria. The gene discussed is FOXP3; the disease is myeloid sarcoma.