Congruently, we have previously shown that infarct size following the intraluminal filament MCAO model of stroke is equivalent in OPN-/- and WT mice (Meller et al., 2005), however, NLRP3-/- and CD36-/- mice have been reported to have smaller infarct volumes compared to WT mice following intraluminal filament MCAO (Cho et al., 2005; Kunz et al., 2008; Yang et al., 2014; Garcia-Bonilla et al., 2015). Here, SPP1 is linked to Stroke.