p11 is expressed in various brain regions (Milosevic et al., 2017), and p11 expressed in the nucleus accumbens (NAc; Alexander et al., 2010; Warner-Schmidt et al., 2012), cerebral cortex (Schmidt et al., 2012; Seo et al., 2017b), hippocampus (Egeland et al., 2010; Oh et al., 2013; Medrihan et al., 2017), and habenula (Seo et al., 2017a) affects depression-like behaviors via a variety of neural mechanisms. The gene discussed is S100A10; the disease is depressive disorder.