Interaction of p11 with its binding proteins such as the 5-HT1B receptor, 5-HT4 receptor and mGluR5 are required for antidepressant action (Svenningsson et al., 2006; Warner-Schmidt et al., 2009; Lee et al., 2015), but the precise p11-mediated mechanisms for CIN activation were unknown. The gene discussed is S100A10; the disease is cervical squamous intraepithelial neoplasia.