HRH4 and asthma: Moreover, pharmacological studies suggest the potential utility of histamine H4 antagonists in the treatment of inflammatory diseases, such as AR, asthma, atopic dermatitis, and pruritus.9, 10, 11, 12, 13 The selective H4R antagonist JNJ7777120 showed efficacy in relieving symptoms and inflammatory conditions in animal models of AR.11, 14 However, these treatments are not curative and they are expensive; additionally, antihistamines may impair performance due to their side effects.15, 16