As leading examples, mutations in ZIP4 (SLC39A4) and ZIP13 (SLC39A13) are responsible for the rare lethal autosomal-recessive inherited zinc deficiency disease, acrodermatitis enteropathica (AE) [78], and Ehlers-Danlos Syndrome (EDS) [79], respectively. This evidence concerns the gene SLC39A4 and acrodermatitis enteropathica.