Conversely, several studies found that GPRC5A expression is elevated in HCC compared to in paratumor and normal liver tissues, and high GPRC5A expression is related to advanced clinical stage, high serum alpha-fetoprotein (AFP), vascular invasion, tumor recurrence, and worse prognosis (OS and disease-free survival) [94, 95]. Here, AFP is linked to hepatocellular carcinoma.