Additionally, overexpression of p53 in the p53-null human nonsmall cell lung cancer (NSCLC) H1299 cells led to increased GPRC5A expression, while p53 knockdown in the p53 wild-type human NSCLC A549 cells resulted in decreased expression of GPRC5A, indicating that GPRC5A is involved in the antitumor effect of p53 in NSCLC cells [31]. This evidence concerns the gene GPRC5A and lung cancer.