The phosphorylation of GPRC5A in two conserved double-tyrosine (TYR) motifs, TYR-317/TYR-320, and TYR-347/TYR-350 is mediated by epidermal growth factor receptor (EGFR), leading to inactivation of the protein's tumor suppressive function [44, 45]. This evidence concerns the gene TYR and neoplasm.