GPRC5A and non-small cell lung carcinoma: Moreover, homozygous GPRC5A knockout mice are more likely to spontaneously develop lung tumors than GPRC5A heterozygous or wild-type mice, with tumor incidence rates of 76%, 11%, and 10%, respectively [78]. In vitro experiments demonstrated that overexpression of GPRC5A inhibits cell viability and colony-formation and enhances apoptosis in NSCLC cell lines [31, 56, 66, 78].