WWTR1 and neoplasm: It consists of cytoplasmic kinases (MST1/2 and LATS1/2) that act as tumor suppressors by restraining the activity of the transcriptional co-activators yes-associated protein (YAP1)/transcriptional co-activator with PDZ-binding motif (TAZ, also known as WWTR1) via phosphorylation, hence preventing their nuclear localization and activation of TEA domain (TEAD) family members transcription factors.