Most importantly, and without any previous molecular analysis, siRNA-mediated XIAP knock down antagonized its upregulation by NFκB and consequently fully re-sensitized conditioned Malme3M to IZI1551 (Fig. 5f, g), confirming that XIAP might be a key player in conferring TRAIL resistance in mutBRAF melanoma cells, and that the DBN developed here was able to predict this key player correctly. This evidence concerns the gene XIAP and melanoma.