NFKB1 and melanoma: Most importantly, and without any previous molecular analysis, siRNA-mediated XIAP knock down antagonized its upregulation by NFκB and consequently fully re-sensitized conditioned Malme3M to IZI1551 (Fig. 5f, g), confirming that XIAP might be a key player in conferring TRAIL resistance in mutBRAF melanoma cells, and that the DBN developed here was able to predict this key player correctly.